ENDOVAC Bovi®-Beef

Protect Your Cattle Against Gram Negative Septicemic Diseases
caused by E.coli, Salmonella sp & Pasteurella sp
With One Vaccine!

The development of a mutant bacterin combined with an immune stimulant has resulted in an effective cross-protective vaccine. This USDA licensed vaccine offers protection against several Gram negative endotoxins, common causes of economic loss to beef and milk producers.

With this unique cross-protective bacterin and immune stimulant broad spectrum protection is achieved more rapidly.

ENDOVAC-Bovi® with Immune Plus® offers the Producer a new option which can reduce the economic losses associated with Gram negative septicemias and endotoxemias in cattle. Recent feedlot studies resulted in a $3.25 per head savings in medicine cost and significant reduction in pulls/re-pulls for vaccinated cattle vs. non-vaccinated cattle. Recently, significant reductions in incidence, sick days and mortality due to E. coli in dairy cows has been demonstrated.

Questions and Answers

What is ENDOVAC-Bovi®?

ENDOVAC-Bovi® is an Re-17 mutant Salmonella typhimurium bacterin-toxoid. This vaccine utilizes an antigen which is devoid of the outer O-side chains resulting in an exposed cell wall. Since the cell walls of gram negative bacteria are virtually analogous, this "core antigen" vaccine provides cross-protection from many gram-negative endotoxemic diseases.

How does ENDOVAC-Bovi® prevent E. coli mastitis?

Independent research has clearly shown the association of endotoxins and the clinical signs of E. coli mastitis. Core-antigen vaccines focus on endotoxins by providing anti-LPS antibodies in response to active immunization. In the largest and most comprehensive efficacy study performed in over 2,600 dairy cattle, ENDOVAC-Bovi® significantly reduced both the incidence and severity of E. coli mastitis due to E. coli, "The first USDA licensed product with this approval".

Can ENDOVAC-Bovi® be used in lactating dairy cattle?

ENDOVAC-Bovi® is not licensed for use in lactating cows. Studies indicated no increase in somatic cell counts or other adverse reactions when ENDOVAC-Bovi® was administered to lactating dairy cattle (studies available via Immvac, Inc.). It is recommended that ENDOVAC-Bovi® be used in the dry period to most effectively immunize cattle prior to the time of the highest incidence of E. coli mastitis during early lactation.

How is ENDOVAC-Bovi® administered?

Inject 2ml into the musculature of healthy cattle. Repeat in 2 or 3 weeks. Administer a 2ml booster dose annually. Not recommended for administration to mastitic cows or to septicemic cattle.

How is ENDOVAC-Bovi® supplied?

ENDOVAC-Bovi® is sold to veterinarians only and is supplied in 20 dose (40ml), 50 dose (100ml) bottles and 100 dose (200mL). ENDOVAC-Bovi® is refrigerated and has a 36 month shelf life.

The ENDOVAC-Bovi® Vaccine "Bottom Line"

1 .ENDOVAC-Bovi® with the ImmunePlus® immuno-stimulant, provides cross-protection against many Gram negative endotoxin associated diseases.

2. With ENDOVAC-Bovi®, protection is achieved more rapidly via our patented ImmunePlus® immuno-stimulant.

3. Significant savings can be realized when costs associated with Mastitis and feedlot problems are reduced.